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深圳相同翻譯公司->翻譯消息->深圳翻譯|乳腺導管原位癌構造學特點與oncotype DX檢測評分的相干性

深圳翻譯|乳腺導管原位癌構造學特點與oncotype DX檢測評分的相干性

來歷:深圳相同翻譯公司

翻譯:

古代病理學雜志

乳腺導管原位癌的Oncotype DX檢測方式用以檢測導管原位癌病人的部分復發危險。檢測成果有助于挑選低危險的導管原位癌病人,激進手術先行噴射醫治。檢測的基因包含5個增殖基因、孕激素受體(PR)和GSTM-1。咱們的目標是鑒定導管原位癌的PR、核割裂計數或別的病理特點是不是能展望導管原位癌Oncotype DX檢測評分。


咱們對46例導管原位癌停止Oncotype DX檢測評分。除慣例病理信息外,計數導管原位癌的核割裂象,記實導管原位癌四周是不是有麋集的慢性炎細胞浸潤。咱們發明:PR ≥90%(P=0.004)、核割裂計數≤1(P=0.045)、雌激素受體≥90%(P=0.046)、低核級(P<0.0001)與導管原位癌Oncotype DX檢測低評分相干。


導管原位癌四周麋集的慢性炎細胞浸潤與Oncotype DX檢測高評分相干(P=0.034)。PR ≥90%、核割裂象≤1且導管原位癌四周缺少麋集慢性炎細胞浸潤的病例有13例,Oncotype DX檢測全數為低評分(特同性100%)。?


低評分不見于最少有以下2項的病例中:PR陽性、核割裂象>1和/或導管原位癌四周有麋集的慢性炎細胞浸潤(特同性100%)。咱們的研討提醒,結合應用PR(≥90%或陽性)、核割裂計數(≤1或>1)和導管原位癌四周麋集的慢性炎細胞浸潤這三個目標,能夠展望乳腺導管原位癌Oncotype DX檢測評分,核割裂計數和免疫反映的評價能夠為乳腺導管原位癌供給預后信息。

原文:

Correlation of histopathologic features of ductal carcinoma in situ of the breast with the oncotype DX DCIS score.

Knopfelmacher A,Fox J,Lo Y,Shapiro N,Fineberg S

Modern Pathology; Sep 2015; 28 (9): 1152 - 1281:1167-73?

The Oncotype DX Breast Cancer Assay for ductal carcinoma in situ is used to determine local recurrence risk in patients with ductal carcinoma in situ. The results help select patients with low-risk ductal carcinoma in situ who could forgo radiation therapy after conservative surgery.?


The genes assessed include five proliferation genes, progesterone receptor (PR), and GSTM-1. Our objective was to determine if PR, mitotic counting, or any other pathologic feature of ductal carcinoma in situ could predict the Oncotype DX DCIS Score. We identified 46 cases of ductal carcinoma in situ with a Oncotype DX DCIS Score. In addition to information obtained from routine pathology, we counted mitotic figures in the ductal carcinoma in situ and noted presence of dense chronic inflammatory infiltrate surrounding ductal carcinoma in situ.?


We found that PR ≥90% (P=0.004), mitotic count ≤1 (P=0.045), estrogen receptor ≥90% (P=0.046), and low nuclear grade (P<0.0001) were associated with a low score. Dense chronic inflammation surrounding ductal carcinoma in situ was associated with a high score (P=0.034).All 13 cases with PR ≥90%, ≤1 mitotic figure and absence of dense chronic inflammation around ductal carcinoma in situ had a low score (100% specificity).?


A low score was not observed in any case with at least two of the following-negative PR, >1 mitotic figure, and/or presence of dense chronic inflammation around ductal carcinoma in situ (100% specificity). Our study suggests using a combination of PR (≥90% vs negative) with mitotic count in ductal carcinoma in situ (≤1 vs >1) and dense chronic inflammation around ductal carcinoma in situ one could predict the Oncotype DX DCIS score. Mitotic counting and evaluation of immune response might provide prognostic information in ductal carcinoma in situ.

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